Preventive effects of montelukast against acetaminophen-induced nephrotoxicity: An experimental study

Objective: Montelukast, an asthma drug, has anti-inflammatory effect on tissues. We aimed to investigate therapeutic of montelukast (MK) acetaminophen (APAP) - induced renal damage in rat models. Material and Methods: Twenty-four rats were randomly divided into four groups six animals each. APAP was administered intraperitoneally as a single dose 1000 mg/kg/day. In the treatment group, MK 10 mg/kg by oral gavage after APAP. The other + Saline group control group. measured tissue malondialdehyde (MDA), reduced glutathione (GSH), Nitric oxide (NO) levels determine nephrotoxicity. Results: Serum Blood Urea Nitrogen (BUN) creatinine significantly higher than groups. level GSH diminished APAP-treated rats. However, administration increased Tissue MDA treated with alone compared NO elevated lower Furthermore, some morphological recoveries observed Conclusion: beneficial effects APAP-induced toxicity dysfunction. clinical studies are needed demonstrate appropriate use effects. Keywords: acetaminophen, kidney, montelukast, nephrotoxicity, oxidative stress